產品英文名稱：Dkk-1 Fc fusion, human,DKKFC-050,50ug
產品中文名稱：人源Dkk-1蛋白Fc融合WNT信號通路抑制劑

Dkk-1 Fc fusion, human,DKKFC-050,50ug 產品簡介
DKK-1是重組人Dickkopf相關蛋白1的簡稱，是DKK蛋白干細胞生長分化調整因子家族（DKK1-4）的一員。DKK蛋白干細胞生長分化調整因子最初被認為是非洲爪蟾蜍的前期成形細胞。通過機理 研究發(fā)現DKK-1通過與共同受體LRP5/6一起形成抑制復合物，可以有效抑制Wnt/β-catenin信號通路。研究人員發(fā)現敲除DKK-1基因小 鼠的腦部無法形成，從而證實Wnt/β-catenin信號通路的抑制在脊椎動物的后模式與前模式發(fā)展中必不可少。
當DKK-1融于人IgG1蛋白的Fc片段時，這種融合避免了蛋白在體內體外環(huán)境下的顯著失活，有效保證了其穩(wěn)定性。

人源Dkk-1蛋白Fc融合WNT信號通路抑制劑,50ug 產品特性
»人源Dkk-1蛋白干細胞生長分化調整因子Fc融合WNT信號通路抑制劑,50ug鑒定純度大于90%
»人源Dkk-1蛋白干細胞生長分化調整因子Fc融合WNT信號通路抑制劑,50ug生物活性在培養(yǎng)人細胞中用TCF受體基因檢測確定，拮抗劑WNT-3a 100 ng/mL時其IC50在200 - 1000 ng/ml之間

Dkk-1 Fc fusion, human,DKKFC-050,50ug 保存方法
The lyophilized protein is stable for at least one year if stored at -80 degreeC. Reconstituted protein is stable for at least four weeks at 4 degree C, but should be stored in aliquots at -80 degree C for longer term. Avoid repeated freeze and thaw.

Dkk-1 Fc fusion, human,DKKFC-050,50ug 產品英文描述
DKK-1, Dickkopf-related protein-1, is a member of the DKK protein family which includes DKK-1 through DDK-4. DKK was originally identified as a head-forming molecule in Xenopus. Mechanistic studies showed that DKK-1 inhibits the Wnt /β-catenin signaling pathway by forming inhibitory complexes with co-receptor LRP5/6. Inhibition of Wnt/β-catenin signaling is essential for posterior patterning and anterior development in vertebrates, supported by the discovery that DKK-1 knockout mice lack head formation. When DKK-1 is fused to the Fc fragment of human IgG1. This fusion renders stability of the protein in vitro and in vivo without significant loss of activity.
StemRD expresses Dkk-1 Fc fusion, human,DKKFC-050,50ug in human 293 cells and purifies it by protein A column.
• Dkk-1 Fc fusion, human,DKKFC-050,50ug Purity Greater than 90% as determined by SDS-PAGE analysis
• Dkk-1 Fc fusion, human,DKKFC-050,50ug Biological Activity The activity was determined by using a TCF reporter gene assay in cultured human cells. The IC50 ranges from 200 - 1000 ng/ml in the inhibition of 100 ng/mL WNT-3a activity. Activity in other assays should be determined by each individual setting.

人源Dkk-1蛋白Fc融合WNT信號通路抑制劑系列產品訂購信息
StemRD DKK-025  25ug  優(yōu)惠價格請來電咨詢
StemRD DKK-100  100ug  優(yōu)惠價格請來電咨詢
StemRD DKK-500  500ug  優(yōu)惠價格請來電咨詢
StemRD DKKFC-050  50ug  優(yōu)惠價格請來電咨詢
StemRD DKKFC-250  250ug  優(yōu)惠價格請來電咨詢
StemRD DKKFC-1000  1000ug  優(yōu)惠價格請來電咨詢
For research use only. Not intended for human or animal diagnostic or therapeutic uses.